Scientifiques

Background scientifique

 Essential bibliography

The CFTR gene is responsible for the production of a protein regulating outflow of water and salts (like chloride Cl^- but also rhodanide SCN^-) from cells that cover internal and external surfaces of the body, the so-called epithelial cells. Inactivation of CFTR is likely to cause multiple defects in the airway that together alter local innate immunity (Childers M, 2007). As shown in recent publications, hypothiocyanite (OSCN^-) antimicrobial molecule (Moskwa P, 2007 and Conner GE) and lactoferrin (Rogan MP, 2004) are deficient in Cystic Fibrosis condition.

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